Journal
TETRAHEDRON LETTERS
Volume 60, Issue 22, Pages 1498-1500Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.04.054
Keywords
Heterocycles; Cycloadditions; Dihydropyridazine; Palladium
Categories
Funding
- Lancaster University
- AstraZeneca CASE Top-Up Award
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A convenient, scalable synthesis of 1,2-dihydropyridazines is presented, based on the Diels-Alder cycloaddition of 1-acetoxy-1,3-butadiene with a variety of azo compounds, followed by a palladium-catalysed elimination. The products are produced on multigram scale and the new method is particularly efficient and atom-economical when compared with previous preparations of 1,2-dihydropyridazines. (C) 2019 Elsevier Ltd. All rights reserved.
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