Journal
TETRAHEDRON LETTERS
Volume 60, Issue 26, Pages 1724-1726Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.05.061
Keywords
Hawaii; Marine; Aspergillus; Fungus; Circumdatin M; NMR; CD
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Funding
- Daniel K. Inouye College of Pharmacy (DKICP), University of Hawaii at Hilo (UHH)
- Victoria S. and Bradley L. Geist Foundation [15ADVC-74420, 17CON-86295]
- Hawaii IDeA Network for Biomedical Research Excellence III (INBRE-III) project: NIGMS [5P20GM103466]
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A new benzodiazepine alkaloid, circumdatin M (1), with a rare pyrimidone-4-pyrone moiety was isolated from a Hawaiian marine fungus Aspergillus sp. FM242. The structure of compound 1 was determined by analysis of HRMS and NMR spectroscopic data, and DP4+ NMR calculations. The absolute configurations of compound 1 were assigned by CD calculations. Compound I was tested inactive against A2780 and A2780CisR. (C) 2019 Elsevier Ltd. All rights reserved.
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