Journal
TETRAHEDRON LETTERS
Volume 60, Issue 14, Pages 989-993Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.03.008
Keywords
Bromination; Potassium persulfate; Imidazo[1,2-alpha]pyridine; Nitrogen-heterocycle
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Funding
- Khon Kaen University
- Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Khon Kaen University
- Center for Innovation in Chemistry (PERCH-CIC), Mahidol University
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A convenient halogenation of 2-arylimidazo[1,2-alpha]pyridines using sodium chloride/bromide/iodide as the halogen sources in the presence of K2S2O8 as an easy-to-handle oxidizing agent was developed. The present work offers an efficient and rapid access to 3-chloro-, 3-bromo- and 3-iodo-2-arylimidazo [1,2-alpha]pyridines which can be readily converted to C3-substituted imidazo[1,2-alpha]pyridines by cross-coupling reactions. (C) 2019 Elsevier Ltd. All rights reserved.
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