Journal
TETRAHEDRON
Volume 75, Issue 31, Pages 4143-4149Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2019.05.047
Keywords
Nickel catalysis; C-H alkylation; Unactivated halides; Carbocyclization
Categories
Funding
- National Institute of General Medical Sciences [R01 GM 107204]
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The development of a nickel-catalyzed C-H alkylation of aromatic substrates with unactivated alkyl halides is described. This carbocyclization facilitates the synthesis of diverse fused ring systems from simple aromatic substrates and is an attractive alternative to traditional polar or radical-mediated ring formations. The present system uses unactivated primary and secondary alkyl bromides and chlorides, while avoiding the use of precious palladium catalysts and more reactive alkyl halides commonly used in related C-H alkylations. (C) 2019 Elsevier Ltd. All rights reserved.
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