Journal
TETRAHEDRON
Volume 75, Issue 25, Pages 3382-3386Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2019.04.046
Keywords
Marine natural products; Caldora penicillata; Cyclic depsipeptide; Serine protease inhibition
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Funding
- JSPS KAKENHI [15K01803]
- University of the Ryukyus Strategic Research Grant
- Grants-in-Aid for Scientific Research [15K01803] Funding Source: KAKEN
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Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC50 values of 0.13 nM and 1.1 mu M. (C) 2019 Elsevier Ltd. All rights reserved.
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