Synthesis, antimicrobial evaluation and docking study of triazole containing triaryl-1H-imidazole

An efficient route for the synthesis of triazole containing triaryl-1H-imidazole (3a-3r) was achieved involving multicomponent condensation of triazole aldehydes, ammonium acetate and 1,2-dicarbonyl compounds in glacial acetic acid. The structure of newly synthesized imidazoles was established by the FTIR, HRMS and NMR spectra. All the compounds displayed considerable antimicrobial activity against fungal and bacterial strains. The triazolyl imidazole 3p was substantially potent against P. aeruginosa (0.0113 mu mol/mL), A. niger (0.0113 mu mol/mL) and C. albicans (0.0056 mu mol/mL) wherein triazolyl imidazoles 3i was found to be more potent against B. subtilis (0.0122 mu mol/mL) & A. niger (0.0121 mu mol/mL); and compound 3r was also found to be more potent against S. epidermidis (0.0117 mu mol/mL) & C. albicans (0.0058 mu mol/mL). As a result of docking studies, the binding affinity of the compound 3o was -9.6 kcal/mol which was even more in comparison to the binding affinity of co-crystallized ligand CBN (-9.4 kcal/mol).