Journal
SYNTHESIS-STUTTGART
Volume 51, Issue 11, Pages 2261-2277Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611773
Keywords
amides; peptides; amino acids; non-classical peptide couplings; carboxylic acid surrogates; amine surrogates
Categories
Funding
- Fonds Wetenschappelijk Onderzoek [FWO Vlaanderen (Research Foundation Flanders)]
- Research Project and Scientific Research Network (WOG)
Ask authors/readers for more resources
The construction of peptidic amide bonds has become a daily laboratory practice by virtue of well-established coupling reagents'. Nonetheless, inherent limitations connected to these classical coupling methods in terms of waste, safety and expense have yet to be conquered. Research efforts have been devoted to synthetic methods able to surpass these limitations. This short review focuses on the advances made in these non-classical' methods for amide bond formation with a specific application in peptide chemistry. It consists of two main sections: (i) novel carboxylic activation reagents, and (ii) carboxylic acid and amine surrogates. 1 Introduction 2 Alternative Carboxylic acid Activation Reagents 3 Carboxylic Acid and Amine Surrogates 4 Conclusion and Perspectives
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available