4.5 Article

Synthesis of N-Pyridyl Hydroxylamines via Copper-Catalyzed Cross-Coupling

Journal

SYNTHESIS-STUTTGART
Volume 51, Issue 15, Pages 2891-2896

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611836

Keywords

copper; cross-coupling; hydroxylamines; protecting groups; pyridine

Funding

  1. U.S. Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) [CB10243]

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N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28-90% yield.

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