Journal
SMALL
Volume 15, Issue 27, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201901065
Keywords
antibacterial; cyclodextrin metal-organic frameworks; silver nanoparticles; stability; wound healing
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Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA12050307]
- National Science and Technology Major Projects for the Major New Drugs Innovation and Development [2018ZX09721002-009]
- Research Foundation of the Shanghai Institute of Materia Medica [CASIMM0120182001]
- CAS-TWAS President's Fellowship Program
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The challenge of bacterial infection increases the risk of mortality and morbidity in acute and chronic wound healing. Silver nanoparticles (Ag NPs) are a promising new version of conventional antibacterial nanosystem to fight against the bacterial resistance in concern of the drug discovery void. However, there are several challenges in controlling the size and colloidal stability of Ag NPs, which readily aggregate or coalesce in both solid and aqueous state. In this study, a template-guided synthesis of ultrafine Ag NPs of around 2 nm using water-soluble and biocompatible gamma-cyclodextrin metal-organic frameworks (CD-MOFs) is reported. The CD-MOF based synthetic strategy integrates AgNO3 reduction and Ag NPs immobilization in one pot achieving dual functions of reduced particle size and enhanced stability. Meanwhile, the synthesized Ag NPs are easily dispersible in aqueous media and exhibit effective bacterial inhibition. The surface modification of cross-linked CD-MOF particles with GRGDS peptide boosts the hemostatic effect that further enhances wound healing in synergy with the antibacterial effect. Hence, the strategy of ultrafine Ag NPs synthesis and immobilization in CD-MOFs together with GRGDS modification holds promising potential for the rational design of effective wound healing devices.
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