Journal
BIOMARKERS IN MEDICINE
Volume 9, Issue 4, Pages 391-401Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/BMM.14.106
Keywords
anti-peptide antibody; NGEP; prognostic factors; prostate cancer
Categories
Funding
- Iran University of Medical Sciences [13146]
- Iranian National Science Foundation [89002533]
Ask authors/readers for more resources
Aim: The aim of this study was to produce a novel polyclonal antibody against extracellular domain of NGEP protein and explore its role in prognosis of prostate cancer. Materials & methods: Polyclonal antibodies against two peptides (NGEP-p1 and NGEP-p2) derived extracellular domains of NGEP were prepared and the intensity and distribution of NGEP expression analyzed in large series of prostate tissue specimens. Results: We found a significant inverse correlation between NGEP expression and prognostic features such as Gleason score, pathologic tumor stage and prostate-specific antigen level using anti-NGEP-p2 antibody. Conclusion: The results indicate that the high level of expression could be associated with good prognosis in prostate cancer. However, additional studies are required to evaluate NGEP as an independent prognostic factor for prostate carcinoma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available