Journal
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56
Volume 56, Issue -, Pages 469-487Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pharmtox-010715-103120
Keywords
adrenomedullin; amylin; CGRP; calcium-sensing receptor; CRF; GPR30; heterodimer; GPCR; RAMP; VIP
Categories
Funding
- NIGMS NIH HHS [R01GM104251, R01 GM104251] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM104251] Funding Source: NIH RePORTER
Ask authors/readers for more resources
It is now recognized that G protein-coupled receptors (GPCRs), once considered largely independent functional units, have a far more diverse molecular architecture. Receptor activity-modifying proteins (RAMPs) provide an important example of proteins that interact with GPCRs to modify their function. RAMPsare able to act as pharmacological switches and chaperones, and they can regulate signaling and/or trafficking in a receptor-dependent manner. This review covers recent discoveries in the RAMP field and summarizes the knownGPCRpartners and functions of RAMPs. Wealso discuss the first peptide-bound structures of RAMP-GPCR complexes, which give insight into the molecular mechanisms that enable RAMPs to alter the pharmacology and signaling of GPCRs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available