Journal
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56
Volume 56, Issue -, Pages 385-402Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pharmtox-010814-124816
Keywords
reconstitution; transporter; purification; vesicular neurotransmitter transporter; SLC17
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Funding
- Grants-in-Aid for Scientific Research [26460067] Funding Source: KAKEN
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Vesicular neurotransmitter transporters are responsible for the accumulation of neurotransmitters in secretory vesicles and play essential roles in chemical transmission. The SLC17 family contributes to sequestration of anionic neurotransmitters such as glutamate, aspartate, and nucleotides. Identification and subsequent cellular and molecular biological studies of SLC17 transporters unveiled the principles underlying the actions of these transporters. Recent progress in reconstitution methods in combination with postgenomic approaches has advanced studies on neurotransmitter transporters. This review summarizes the molecular properties of SLC17-type transporters and recent findings regarding the novel SLC18 transporter.
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