Journal
ANNUAL REVIEW OF MEDICINE, VOL 67
Volume 67, Issue -, Pages 433-451Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-062613-093100
Keywords
inflammation; plasticity; peripheral; pain; addiction; tolerance
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Opioids are the oldest and most potent drugs for the treatment of severe pain. Their clinical application is undisputed in acute (e.g., postoperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny. This article reviews mechanisms underlying opioid analgesia and other opioid actions. It discusses the structure, function, and plasticity of opioid receptors; the central and peripheral sites of analgesic actions and side effects; endogenous and exogenous opioid receptor ligands; and conventional and novel opioid compounds. Challenging clinical situations, such as the tension between chronic pain and addiction, are also illustrated.
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