Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 34
Volume 34, Issue -, Pages 151-172Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-041015-055435
Keywords
BTN1A; BTN2A; BTN3A; B30.2; PRYSPRY
Categories
Funding
- Medical Research Council [MR/M020290/1] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0901682] Funding Source: researchfish
- MRC [G0901682, MR/M020290/1] Funding Source: UKRI
Ask authors/readers for more resources
Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the eponymous protein in cow's milk. They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276). These coreceptors modulate T cell responses upon antigen presentation by major histocompatibility complex and cognate alpha beta T cell receptor engagement. Molecules such as BTN3A1 (CD277), myelin oligodendrocyte glycoprotein, and mouse Skint1 and Btnl2, all members of the butyrophilin family, show greater structural and functional diversity than the canonical B7 receptors. Some butyrophilins mediate complex interactions between antigen-presenting cells and conventional alpha beta T cells, and others regulate the immune responses of specific gamma delta T cell subsets by mechanisms that have characteristics of both innate and adaptive immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available