Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 34
Volume 34, Issue -, Pages 369-394Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-041015-055427
Keywords
vitamin A; adaptive immunity; innate immunity; genomic; nongenomic; gene expression
Categories
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050265, R01AI064584] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI064584, R01 AI050265] Funding Source: Medline
Ask authors/readers for more resources
Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity. This is especially key at the intestinal border, where dietary vitamin A is first absorbed. Most effects of vitamin A are exerted by its metabolite, retinoic acid (RA), which through ligation of nuclear receptors controls transcriptional expression of RA target genes. In addition to this canonical function, RA and RA receptors (RARs), either as ligand-receptor or separately, play extranuclear, nongenomic roles that greatly expand the multiple mechanisms employed for their numerous and paradoxical functions that ultimately link environmental sensing with immune cell fate. This review discusses RA and RARs and their complex roles in innate and adaptive immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available