Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 34
Volume 34, Issue -, Pages 511-538Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-041015-055347
Keywords
PKC; hematopoiesis; immune system; signal transduction; enzyme regulation
Categories
Ask authors/readers for more resources
The protein kinase C (PKC) family, discovered in the late 1970s, is composed of at least 10 serine/threonine kinases, divided into three groups based on their molecular architecture and cofactor requirements. PKC enzymes have been conserved throughout evolution and are expressed in virtually all cell types; they represent critical signal transducers regulating cell activation, differentiation, proliferation, death, and effector functions. PKC family members play important roles in a diverse array of hematopoietic and immune responses. This review covers the discovery and history of this enzyme family, discusses the roles of PKC enzymes in the development and effector functions of major hematopoietic and immune cell types, and points out gaps in our knowledge, which should ignite interest and further exploration, ultimately leading to better understanding of this enzyme family and, above all, its role in the many facets of the immune system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available