Journal
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 17
Volume 17, Issue -, Pages 69-94Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-090314-024939
Keywords
lncRNA; Xist; roX; transcription; genome regulation
Categories
Funding
- NICHD NIH HHS [DP2 HD083992] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007223] Funding Source: Medline
Ask authors/readers for more resources
Beyond coding for proteins, RNA molecules have well-established functions in the posttranscriptional regulation of gene expression. Less clear are the upstream roles of RNA in regulating transcription and chromatin-based processes in the nucleus. RNA is transcribed in the nucleus, so it is logical that RNA could play diverse and broad roles that would impact human physiology. Indeed, this idea is supported by well-established examples of noncoding RNAs that affect chromatin structure and function. There has been dramatic growth in studies focused on the nuclear roles of long noncoding RNAs (lncRNAs). Although little is known about the biochemical mechanisms of these lncRNAs, there is a developing consensus regarding the challenges of defining lncRNA function and mechanism. In this review, we examine the definition, discovery, functions, and mechanisms of lncRNAs. We emphasize areas where challenges remain and where consensus among laboratories has underscored the exciting ways in which human lncRNAs may affect chromatin biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available