Journal
ANNUAL REVIEW OF GENETICS, VOL 50
Volume 50, Issue -, Pages 1-28Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120215-035043
Keywords
homologous recombination; nonhomologous end-joining; site-specific endonuclease; budding yeast mating type-switching; DNA repair; DNA damage checkpoint
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Funding
- NIGMS NIH HHS [R01 GM076020] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076020] Funding Source: NIH RePORTER
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Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of our understanding of these pathways has come from the analysis of site-specific DSBs created by the HO endonuclease in the budding yeast Saccharomyces cerevisiae. I was fortunate to get in on the ground floor of analyzing the fate of synchronously induced DSBs through the study of what I coined in vivo biochemistry. I have had the remarkable good fortune to profit from the development of new techniques that have permitted an ever more detailed dissection of these repair mechanisms, which are described here.
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