Journal
SEMINARS IN CANCER BIOLOGY
Volume 59, Issue -, Pages 112-124Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.04.001
Keywords
Epigenetic modifications; PI3K/AKT pathway; DNA methylation; Histone methylation/acetylation; Non-coding RNAs
Categories
Funding
- Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University [XJTU1AF-CRF-2017-003]
- National Natural Science Foundation of China [81572627, 81770787]
Ask authors/readers for more resources
Epigenetic alterations, along with genetic alterations, have long been regarded as the most important mechanism participating in carcinogenesis. DNA methylation, histone modifications, and RNA-mediated regulation are involved in many cellular processes that are essential to cancer initiation and progression. A plethora of chromatin-associated proteins and modifying proteins take control of these processes and they are under the modulation of signaling pathways. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway (PI3K/AKT) is in manage of multiple biological processes and is frequently aberrantly activated in human cancers. Increasing evidence has demonstrated that critical epigenetic modifiers are directly or indirectly modulated by PI3K/AKT signaling, and participate in oncogenicity of PI3K cascade in cancers. In this review, we revisit the mechanism of the PI3K/AKT signaling pathway modulating epigenetic reprogramming in cancer and attempt to establish the connection between PI3K/AKT cascade and the epigenome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available