Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 666, Issue -, Pages 1003-1010Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2019.02.208
Keywords
Manganese; Cognitive function; Olfactory function; Biomarker; Neutron activation analysis
Categories
Funding
- Natural Science Foundation of Guizhou Province Scientific and Technology Department Grant [2017-1215]
- International Scientific and Technology Cooperation Project of Guizhou Province [G2014-7012]
- Innovative Talent Team Training Project of Zunyi City [2015-42]
- U.S. Centers for Disease Control and Prevention, National Institute of Occupational Health Science [R21-OH010700]
- U.S. National Institutes of Health/National Institute of Environmental Health Sciences [R01-ES008146, R01-ES027078]
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Occupational manganese (Mn) exposure has been associated with cognitive and olfactory dysfunction; however, few studies have incorporated cumulative biomarkers of Mn exposure such as bone Mn (BnMn). Our goal was to assess the cross-sectional association between BnMn, blood Mn (BMn), and fingernail Mn (FMn) with cognitive and olfactory function among Mn-exposed workers. A transportable in vivo neutron activation analysis (IVNAA) system was designed and utilized to assess BnMn among 60 Chinese workers. BMn and FMn were measured using inductively coupled plasma mass spectrometry. Cognitive and olfactory function was assessed using Animal and Fruit Naming tests, World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test (AVLT) and the University of Pennsylvania Smell Identification Test (UPSIT). Additional data were obtained via questionnaire. Regression models adjusted for age, education, factory of employment, and smoking status (UP.SfT only), were used to assess the relationship between Mn biomarkers and test scores. In adjusted models, increasing BnMn was significantly associated with decreased performance on average AVLT scores [beta (95% confidence interval (CI)) -0.65 (-121, -0.09)] and Animal Naming scores [beta (95% CI) -1.54 (-3.00, -0.07)]. Increasing FMn was significantly associated with reduced performance measured by the average AVLT [beta (95% CI) -0.35 (-0.70, -0.006)] and the difference in AVLT scores [beta (95% CI) -0.40 (-0.77, -0.03)]. BMn was not significantly associated with any test scores; no significant associations were observed with Fruit Naming or UPSIT tests. BnMn and FMn, but not BMn are associated with cognitive function in Mn-exposed workers. None of the biomarkers were significantly associated with olfactory function. (C) 2019 Elsevier B.V. All rights reserved.
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