Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 684, Issue -, Pages 657-669Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2019.05.071
Keywords
Plastic; Polypropylene microplastics; Immune response; Cytokines; Hypersensitivity
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2018M3C1B9066755]
- National Research Foundation of Korea [2018M3C1B9066755] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Environmental pollution caused by plastic waste is a growing global problem. Discarded plastic products and debris (microplastic particles) in the oceans detrimentally affect marine ecosystems and may impact human. Humans are exposed to plastic debris via the consumption of seafood and drinking water, contact with food packaging, or inhalation of particles. The accumulation of microplastic particles in humans has potential health risks such as cytotoxicity, hypersensitivity, unwanted immune response, and acute response like hemolysis. We investigated the cellular responses of secondary polypropylene microplastics (PP particles) of approximately similar to 20 mu m and 25-200 mu m in different condition and size to normal cells, immune cells, blood cells, and murine immune cells by cytokine analysis, ROS assay, polarization assay and proliferation assay. We found that PP particles showed low cytotoxicity effect in size and concentration manner, however, a high concentration, small sized, DMSO method of PP particles stimulated the immune system and enhanced potential hypersensitivity to PP particles via an increase in the levels of cytokines and histamines in PBMCs, Raw 264.7 and HMC-1 cells. (C) 2019 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available