Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 18
Volume 18, Issue -, Pages 25-49Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-082615-030519
Keywords
C-type lectin receptors; Toll-like receptors; folate receptors; brain drug delivery; cancer; drug delivery vehicles
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Pattern recognition receptors on innate immune cells play an important role in guiding how cells interact with the rest of the organism and in determining the direction of the downstream immune response. Recent advances have elucidated the structure and function of these receptors, providing new opportunities for developing targeted drugs and vaccines to treat infections, cancers, and neurological disorders. C-type lectin receptors, Toll-like receptors, and folate receptors have attracted interest for their ability to endocytose their ligands or initiate signaling pathways that influence the immune response. Several novel technologies are being developed to engage these receptors, including recombinant antibodies, adoptive immunotherapy, and chemically modified antigens and drug delivery vehicles. These active targeting technologies will help address current challenges facing drug and vaccine delivery and lead to new tools to treat human diseases.
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