Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 18
Volume 18, Issue -, Pages 181-205Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-110315-020137
Keywords
tolerance; immunomodulation; cell therapies; nanotechnology; inverse vaccines
Categories
Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB009910, R01EB013198] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK020572] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS026543] Funding Source: NIH RePORTER
- NIBIB NIH HHS [R01 EB013198, R01 EB009910] Funding Source: Medline
- NIDDK NIH HHS [P30 DK020572] Funding Source: Medline
- NINDS NIH HHS [R01 NS026543] Funding Source: Medline
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The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve non-specific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self-or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.
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