Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85
Volume 85, Issue -, Pages 35-64Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060815-014451
Keywords
mammalian aging; nutrient sensing; insulin-like signaling; mitochondrial health; proteostasis; oxidative stress; inflammation; telomere shortening; DNA damage; epigenetic regulation
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The health of an organism is orchestrated by a multitude of molecular and biochemical networks responsible for ensuring homeostasis within cells and tissues. However, upon aging, a progressive failure in the maintenance of this homeostatic balance occurs in response to a variety of endogenous and environmental stresses, allowing the accumulation of damage, the physiological decline of individual tissues, and susceptibility to diseases. What are the molecular and cellular signaling events that control the aging process and how can this knowledge help design therapeutic strategies to combat age-associated diseases? Here we provide a comprehensive overview of the evolutionarily conserved biological processes that alter the rate of aging and discuss their link to disease prevention and the extension of healthy life span.
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