Journal
RUSSIAN CHEMICAL BULLETIN
Volume 68, Issue 4, Pages 836-840Publisher
SPRINGER
DOI: 10.1007/s11172-019-2493-4
Keywords
Fischer indole synthesis; isocryptolepine; reduction; one-pot synthesis; indole; Cryptolepis Sanguinolenta
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Funding
- Russian Science Foundation [17-73-10301]
- Russian Science Foundation [17-73-10301] Funding Source: Russian Science Foundation
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A novel one-pot method based on the sequence of the Fisher reaction between nitroacetophenone and phenylhydrazines, the reduction with metallic tin directly in polyphosphoric acid, and acylation has been developed for the synthesis of indoloquinolines. The obtained indolo-[3,2-c]quinolines are precursors of the analogs of isocryptolepine alkaloid.
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