Journal
BIOMARKERS IN MEDICINE
Volume 9, Issue 5, Pages 473-482Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm.15.13
Keywords
angiogenesis; HIV-related diffuse large B-cell lymphoma; Hodgkin's lymphoma; immunosurveillance; impact of highly active antiretroviral therapy; p17; Tat; tumor microenvironment
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Funding
- NIH from the National Cancer Institute [P01 CA81538]
- NATIONAL CANCER INSTITUTE [P01CA081534] Funding Source: NIH RePORTER
- National Institute for Health Research [ACF-2014-19-001] Funding Source: researchfish
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There has been considerable interest in the role of the lymphoma microenvironment. Despite the use of highly active antiretroviral therapy (HAART), AIDS-related diffuse large-B-cell lymphoma remains common and HIV-relatedHIV-associated classical Hodgkin's lymphoma is increasing in incidence. Less is known about the impact HIV and HAART have on the lymphoma microenvironment. AIDS-related diffuse large B-cell lymphoma is highly angiogenic, demonstrates increased lymphoblastic histology, proliferation, increased activated cytotoxic T cells, reduced CD4(+) and FOXP3(+) T cells, but no differences in tumor-associated macrophages. Early initiation of HAART improves immunosurveillance, but cases without viral antigens appear able to avoid immunologic reaction. Increased T cell infiltrates seen with HAART treatment in HIV-related classical Hodgkin's lymphoma may contribute to malignant cell growth.
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