Journal
BIOMARKERS
Volume 21, Issue 2, Pages 129-137Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1118544
Keywords
serum microRNA; RT-qPCR; Biomarker; Parkinson's disease
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Funding
- National Basic Research Program of China (973 Program) [2014CB542300]
- National Natural Science Foundation of China [81250044, 81170309, 81101330, 31271378, 81472021, 81401257]
- Natural Science Foundation of Jiangsu Province [BK2011013, BK2012014, BK20140730]
- Research Special Fund for Public Welfare Industry of Health [201302018]
- Medical Scientific Research Foundation of Nanjing Military Command [12Z28]
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Context: Sensitive, non-invasive biomarkers that facilitate Parkinson's disease (PD) detection and stage assignment are currently unavailable. Objective: The objective of this study is to investigate the potential of circulating microRNAs (miRNAs) as novel biomarkers for PD. Materials and methods: Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients. Results: Serum miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in PD patients compared with controls. Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls. Discussion and conclusion: The four serum miRNAs may represent novel biomarkers for the early detection of PD.
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