Journal
RADIOTHERAPY AND ONCOLOGY
Volume 133, Issue -, Pages 16-19Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2018.12.022
Keywords
Dose painting radiotherapy; Radioresistance; Misonidazole; FAZA; IMRT
Funding
- Programme d'Action Integre de Recherche (PAIR PROSTATE 2010)
- Institut National du Cancer (INCA)
- Association pour La Recherche sur le Cancer (ARC)
- Ligue contre le Cancer
- Region Pays-de Loire
- Region Bretagne
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Hypoxia is a major risk factor of prostate cancer radioresistance. We evaluated hypoxia non-invasively, using F-18-Misonidazole PET/ CT prior to radiotherapy and after a dose of 20 Gy in intermediate-risk prostate cancer patients. Decreased hypoxic volumes were observed in all patients, suggesting that radiotherapy induces early prostate tumor reoxygenation. (C) 2019 Elsevier B.V. All rights reserved.
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