Journal
BIOMARKERS
Volume 20, Issue 6-7, Pages 404-410Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1094135
Keywords
Inflammation; multi-center randomized study; oxidative stress; risk continuum
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A randomized, multi-center study of adult cigarette smokers switched to tobacco-heating cigarettes, snus or ultra-low machine yield tobacco-burning cigarettes (50/group) for 24 weeks was conducted. Evaluation of biomarkers of biological effect (e.g. inflammation, lipids, hypercoaguable state) indicated that the majority of consistent and statistically significant improvements over time within each group were observed in markers of inflammation. Consistent and statistically significant differences in pairwise comparisons between product groups were not observed. These findings are relevant to the understanding of biomarkers of biological effect related to cigarette smoking as well as the risk continuum across various tobacco products (ClinicalTrials.gov Identifier: NCT02061917).
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