Journal
PSYCHONEUROENDOCRINOLOGY
Volume 102, Issue -, Pages 236-247Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2018.12.233
Keywords
Depression; Plasticity; LTP; LTD; Microglia
Categories
Funding
- Medical Research Council (UK) [MR/N029488/1]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- UK National Institute for Health Research (NIHR) Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King's College London
- UK Medical Research Council [MR/N029488/1, MR/L014815/1, MR/J002739/1]
- Psychiatry Research Trust
- MRC [MR/N029488/1, G108/603, MR/J002739/1, MR/L014815/1] Funding Source: UKRI
Ask authors/readers for more resources
Recent data gathered from both in vitro and in vivo models of Major Depressive Disorder (MDD) have indicated that microglia play an active role in modifying some of the most important sources for neuronal plasticity, specifically long-term potentiation (LW) and long-term depression (LTD). In addition, microglia have been implicated in neuro-immune interaction dysregulations, which are considered a core constituent of MDD pathology. While prior studies have investigated the diverse effects activated microglia can have in the context of depression, including regulation of inflammatory cytokine production and structural changes, recent evidence has revealed a more direct relationship between microglial activation and changes in synaptic function and plasticity, including LW and LTD. Here we review these findings from animal models, as well as discuss how current preclinical evidence might shed light on novel therapeutic targets for patients with depressive disorder.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available