4.6 Review

Mammalian sphingoid bases: Biophysical, physiological and pathological properties

Journal

PROGRESS IN LIPID RESEARCH
Volume 75, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2019.100988

Keywords

-

Funding

  1. Fundacao para a Ciencia e Tecnologia (FCT), Portugal [PTDC/BBB-BQB/3710/2014, PTDC/BBB-BQB/6071/2014, PTDC/BIA-BFS/29448/2017, UID/Multi/00612/2019, SFRH/BD/88194/2012, SFRH/BD/102933/2014]
  2. Swiss National Foundation SNF [31003A_179371/1]
  3. Novartis Foundation
  4. Rare Disease Initiative Zurich (radiz, Clinical Research Priority Program for Rare Diseases, University of Zurich)
  5. FCT [IF/00437/2014]
  6. Swiss National Science Foundation (SNF) [31003A_179371] Funding Source: Swiss National Science Foundation (SNF)
  7. Fundação para a Ciência e a Tecnologia [PTDC/BBB-BQB/6071/2014, PTDC/BBB-BQB/3710/2014, SFRH/BD/102933/2014, SFRH/BD/88194/2012, PTDC/BIA-BFS/29448/2017] Funding Source: FCT

Ask authors/readers for more resources

Sphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules, and have been associated with numerous biological and physiological processes. In addition, they can modulate the biophysical properties of biological membranes. Several human diseases are related to pathological changes in the structure and metabolism of sphingoid bases. Yet, the mechanisms underlying their biological and pathophysiological actions remain elusive. Within this review, we aimed to summarize the current knowledge on the biochemical and biophysical properties of the most common sphingoid bases and to discuss their importance in health and disease.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available