Journal
PROGRESS IN LIPID RESEARCH
Volume 74, Issue -, Pages 18-30Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2019.01.004
Keywords
-
Funding
- Ministry of Human Capacities [UP MS KA-2018-05, UNKP-18-4-PTE-26]
- DFG [SFB824-3]
- STA [1520/1-1]
- BMBF [01GU0823]
- BMWi (AiF) [ZF4320102CS7]
- MRC [MR/P007651/1]
- BBSRC [BB/S002774/1]
- EU [666918]
- Action Medical Research
- Danish National Research Foundation [DNRF125]
- European Research Council [AdG 340751]
- Danish Cancer Society [R167 -A11061]
- Danish Council for Independent Research [DFF-7016-00360]
- Novo Nordisk Foundation [NNF15OC0016914]
- [GINOP-2.3.2-15- 2016-00049]
- [GINOP-2.3.3-15-2016-00025]
- [GINOP-2.3.2-15-2016-00040]
- BBSRC [BB/S002774/1] Funding Source: UKRI
- MRC [MR/P007651/1] Funding Source: UKRI
Ask authors/readers for more resources
Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can be recognized by the immune system. Disease-coupled lipid-associated functions of Hsp70 may be targeted via distinct subcellular localizations of Hsp70 itself or its specific interacting lipids. With a special focus on interacting lipids, here we discuss localization-dependent roles of the membrane-bound Hsp70 in the context of its therapeutic potential, particularly in cancer and neurodegenerative diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available