Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 23, Pages 11116-11118Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1903054116
Keywords
alpha synuclein; synapsin; neurotransmission
Categories
Funding
- Israel Science Foundation [1427/12]
- NIH/National Institute on Aging [P50AG005131, R01AG048218]
Ask authors/readers for more resources
The normal function of alpha-synuclein (alpha-syn) remains elusive. Although recent studies suggest alpha-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of alpha-syn. Our data offer a critical missing link and advocate a model where alpha-syn and synapsin cooperate to cluster SVs and attenuate recycling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
