Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 19, Pages 9417-9422Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1902526116
Keywords
shugoshin; meiosis; nonexchange chromosome; centromere pairing; PP2A
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Funding
- Spanish Ministry of Economy and Competitiveness [BFU2017-89408-R]
- Programa de Apoyo a Planes Estrategicos de Investigacion de Estructuras de Investigacion de Excelencia
- European Regional Development Fund [CLC-2017-01]
- Centers of Biomedical Research Excellence [GM103636]
- March of Dimes [FY14-256]
- NIH [R01 GM087377]
- Castilla-Leon autonomous government
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Faithful chromosome segregation during meiosis I depends upon the formation of connections between homologous chromosomes. Crossovers between homologs connect the partners, allowing them to attach to the meiotic spindle as a unit, such that they migrate away from one another at anaphase I. Homologous partners also become connected by pairing of their centromeres in meiotic prophase. This centromere pairing can promote proper segregation at anaphase I of partners that have failed to become joined by a crossover. Centromere pairing is mediated by synaptonemal complex (SC) proteins that persist at the centromere when the SC disassembles. Here, using mouse spermatocyte and yeast model systems, we tested the role of shugoshin in promoting meiotic centromere pairing by protecting centromeric synaptonemal components from disassembly. The results show that shugoshin protects the centromeric SC in meiotic prophase and, in anaphase, promotes the proper segregation of partner chromosomes that are not linked by a crossover.
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