Journal
BIOMARKERS
Volume 20, Issue 6-7, Pages 355-364Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1093546
Keywords
Non-communicable diseases; normalization; plasma protein biomarkers; proximity extension assay
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Funding
- SNIC through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) [b2011203, p2013140]
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Objective: To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance.Materials and methods: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases.Results: Genetic and lifestyle factors explained 20-88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%.Conclusion: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
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