Journal
BIOMACROMOLECULES
Volume 16, Issue 8, Pages 2482-2492Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.5b00758
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Funding
- North Carolina State University [2014-0793]
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Toward our goal of scalable, antimicrobial materials based on photodynamic inactivation, paper sheets comprised of photosensitizer-conjugated cellulose fibers were prepared using porphyrin and BODIPY photosensitizers, and characterized by spectroscopic (infrared, UV-vis diffuse reflectance, inductively coupled plasma optical emission) and physical (gel permeation chromatography, elemental, and thermal gravimetric analyses) methods. Antibacterial efficacy was evaluated against Staphylococcus aureus (ATCC-2913), vancomycin-resistant Enterococcus faecium (ATCC-2320), Acinetobacter baumannii (ATCC-19606), Pseudomonas aeruginosa (ATCC-9027), and Klebsiella pneumoniae (ATCC-2146). Our best results were achieved with a cationic porphyrin paper conjugate, Por((+))-paper, with inactivation upon illumination (30 min, 65 +/- 5 mW/cm(2), 400-700 nm) of all bacterial strains studied by 99.99+% (4 log units), regardless of taxonomic classification. Por(+)-paper also inactivated dengue-1 virus (>99.995%), influenza A (similar to 99.5%), and human adenovirus-5 (similar to 99%). These results demonstrate the potential of cellulose materials to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action.
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