Journal
PAIN MEDICINE
Volume 20, Issue 12, Pages 2459-2471Publisher
OXFORD UNIV PRESS
DOI: 10.1093/pm/pnz015
Keywords
MicroRNAs; Intervertebral Disc Degeneration; Bioinformatic Analysis; Apoptosis; Cell Proliferation
Categories
Funding
- National Natural Science Foundation of China [81871844]
- Shanghai Key Lab of Human Performance (Shanghai University of Sport) [11DZ2261100]
- Fok Ying-Tong Education Foundation of China [161092]
- Shanghai Municipal Commission of Health and Family Planning [201840346]
- Shanghai Education Development Foundation
- Shanghai Municipal Education Commission [18SG48]
- National Key R&D Program of China [2018YFC1314700]
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Objectives. The aim of our study was to ascertain the underlying role of microRNAs (miRNAs) in human intervertebral disc degeneration (IDD). Design. Bioinformatic analysis from multiple databases. Methods. Studies of the association of miRNAs and IDD were identified in multiple electronic databases. All potential studies were assessed by the same inclusion and exclusion criteria. We recorded whether miRNA expression was commonly increased or suppressed in the intervertebral disc tissues and cells of IDD subjects. We used String to identify biological process and cellular component pathways of differentially expressed genes. Results. We included fifty-seven articles from 1,277 records in this study. This report identified 40 different dysregulated miRNAs in 53 studies, including studies examining cell apoptosis (26 studies, 49.06%), cell proliferation (15 studies, 28.3%), extracellular matrix (ECM) degradation (10 studies, 18.86%), and inflammation (five studies, 9.43%) in IDD patients. Three upregulated miRNAs (miR-19b, miR-32, miR-130b) and three downregulated miRNAs (miR-31, miR-124a, miR-127-5p) were considered common miRNAs in IDD tissues. The top three biological process pathways for upregulated miRNAs were positive regulation of biological process, nervous system development, and negative regulation of biological process, and the top three biological process pathways for downregulated miRNAs were negative regulation of gene expression, intracellular signal transduction, and negative regulation of biological process. Conclusions. This study revealed that miRNAs could be novel targets for preventing IDD and treating patients with IDD by regulating their target genes. These results provide valuable information formedical professionals, IDD patients, and health care policy makers.
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