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ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
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p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
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Amyloid-β Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3β in Primary Cultured Hippocampal Neurons
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Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
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A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
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Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
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NATURE (2010)
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
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NATURE CELL BIOLOGY (2010)
Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS
Adrian Israelson et al.
NEURON (2010)
Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1
Guido Krebiehl et al.
PLOS ONE (2010)
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Elena Ziviani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
Des R. Richardson et al.
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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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PLOS BIOLOGY (2010)
The dorsal root ganglion in Friedreich's ataxia
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ACTA NEUROPATHOLOGICA (2009)
Complex I and ATP Content Deficiency in Lymphocytes from Friedreich's Ataxia
Mohammad Mehdi Heidari et al.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2009)
Divalent metal transporter 1 is involved in amyloid precursor protein processing and A beta generation
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FASEB JOURNAL (2009)
Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis
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JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2009)
Correlation of Iron in the Hippocampus with MMSE in Patients with Alzheimer's Disease
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JOURNAL OF MAGNETIC RESONANCE IMAGING (2009)
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
Will Stoothoff et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial (vol 7, pg 779, 2008)
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LANCET NEUROLOGY (2009)
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
Pei-Chun Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant
Michael Li-Hsuan Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mitofusin 2: A mitochondria-shaping protein with signaling roles beyond fusion
Olga Martins De Brito et al.
ANTIOXIDANTS & REDOX SIGNALING (2008)
Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane
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CELL DEATH AND DIFFERENTIATION (2008)
Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
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CIRCULATION RESEARCH (2008)
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
Shih-Ching Lo et al.
EXPERIMENTAL CELL RESEARCH (2008)
Proteomic and oxidative stress analysis in human brain samples of Huntington disease
M. Alba Sorolla et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease
Veerle Bogaerts et al.
HUMAN MUTATION (2008)
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class
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MOLECULAR PHARMACOLOGY (2008)
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
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NATURE MEDICINE (2008)
The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation
Megan Whitnall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease:: a phase IIa, double-blind, randomised, placebo-controlled trial
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LANCET NEUROLOGY (2008)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
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HUMAN MOLECULAR GENETICS (2007)
Mitochondrial ferritin expression in adult mouse tissues
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JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2007)
Localization of α-synuclein to mitochondria within midbrain of mice
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NEUROREPORT (2007)
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Astroglia overexpressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury
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JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Neuronal apoptosis in neurodegeneration
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ANTIOXIDANTS & REDOX SIGNALING (2007)
Selective iron chelation in Friedreich ataxia:: biologic and clinical implications
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BLOOD (2007)
Direct interorganellar transfer of iron from endosome to mitochondrion
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BLOOD (2007)
Mitochondria as key components of the stress response
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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2007)
GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cardiolipin: Setting the beat of apoptosis
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APOPTOSIS (2007)
A new activating role for CO in cardiac mitochondrial biogenesis
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JOURNAL OF CELL SCIENCE (2007)
Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated keap1-dependent ubiquitin ligase complex
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
In vivo modulation of the Parkinsonian phenotype by Nrf2
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Oxidative damage in Huntington's disease pathogenesis
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ANTIOXIDANTS & REDOX SIGNALING (2006)
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
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NATURE (2006)
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
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CELL (2006)
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Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
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HUMAN MOLECULAR GENETICS (2006)
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Mitoferrin is essential for erythroid iron assimilation
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Mice lacking alpha-synuclein are resistant to mitochondrial toxins
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ACTA NEUROPATHOLOGICA (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
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HUMAN MOLECULAR GENETICS (2006)
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LANCET NEUROLOGY (2006)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
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Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant Huntingtin
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HUMAN MOLECULAR GENETICS (2005)
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NEURON (2005)
DJ-1 is present in a large molecular complex in human brain tissue and interacts with α-synuclein
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Iron trafficking in the mitochondrion: novel pathways revealed by disease
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HUMAN MOLECULAR GENETICS (2005)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
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SCIENCE (2004)
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EXPERIMENTAL NEUROLOGY (2004)
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SCIENCE (2004)
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FEBS LETTERS (2004)
Heme oxygenase expression in human central nervous system disorders
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FREE RADICAL BIOLOGY AND MEDICINE (2004)
Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
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HUMAN MOLECULAR GENETICS (2004)
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
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NEURON (2004)
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
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NEURON (2004)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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SCIENCE (2004)
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CELL (2004)
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CLINICAL NEUROSCIENCE RESEARCH (2003)
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JOURNAL OF CELL BIOLOGY (2003)
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NATURE STRUCTURAL BIOLOGY (2002)
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NATURE MEDICINE (2002)
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NEURON (2002)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
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FEBS LETTERS (2001)
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MOLECULAR BIOLOGY OF THE CELL (2001)
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