Journal
ORGANIC LETTERS
Volume 21, Issue 8, Pages 2536-2540Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00263
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Funding
- Thousand Youth Talents Plan, NSFC [21672145, 51733007, 21702135, 21871178]
- Shuguang program from SEDF [16SG10]
- STCSM [17JC1403700]
- Drug Innovation Major Project of the Ministry of Science and Technology of China [2018ZX09711001-005-002]
- Shuguang program from SMEC [16SG10]
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The first examples of electrochemical trifluoromethylation and sulfonylation/semipinacol rearrangements of allylic alcohols were developed using cheap and stable RSO2Na (R = CF3, Ph) as reagents. Various beta-trifluoromethyl and sulfonated ketones were obtained in moderate to excellent yields. This strategy provides a facile, direct, and complementary approach to construct all-carbon quaternary stereocenters. In addition, the reaction has the advantages of being chemical oxidant-free and metal-free and has safe and mild reaction conditions.
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