Journal
ORGANIC LETTERS
Volume 21, Issue 10, Pages 3701-3705Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01164
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Funding
- National Natural Science Foundation of China [21772072, 21502078]
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A nickel-catalyzed reductive coupling between acid fluorides and vinyl triflates has been described. This method provides an efficient access to various enones and avoids the requirement for acyl or vinyl metallic reagents in the conventional approaches. The reaction proceeds with a broad range of acid fluorides and cyclic vinyl triflates, tolerating several functional groups. The utility of this synthetic method has been demonstrated by the late-stage modification of pharmaceuticals and biologically active natural compounds.
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