Journal
ORGANIC LETTERS
Volume 21, Issue 10, Pages 3625-3630Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01048
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Funding
- Beijing Municipal Science AMP
- Technology Commission [Z161100000116032]
- Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease
- Tsing-Peking Centre for Life Science
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Decarboxylative cross-coupling of aliphatic acid anhydrides with vinyl triflates or halides was accomplished via nickel catalysis. This methodology works well with a broad array of substrates and features abundant functional group tolerance. Notably, our approach addresses the issue of safe and environmental installation of methyl or ethyl group into molecular scaffolds. The method possesses high chemoselectivity toward alkyl groups when aliphatic/aromatic mixed anhydrides are involved. Furthermore, diverse ketones could be modified with our strategy.
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