Journal
ORGANIC LETTERS
Volume 21, Issue 10, Pages 3785-3788Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01237
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Funding
- NSFC [21861142005, 21572100, 81773591, 81530089, 81673333, 81803380, 21761142001, 21661140001]
- MOST [2018YFC1706205]
- Fundamental Research Funds for the Central Universities [020814380092, 020814380113]
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Genome mining of the marine Streptomyces seoulensis A01 enabled the identification of a giant type I polyketide synthase gene cluster (asm). Heterologous expression of the cryptic asm cluster using a bacterial artificial chromosome vector in heterologous host led to the production of ansaseomycins A (1) and B (2). A plausible biosynthetic pathway was also proposed. Additionally, compounds 1 and 2 are active against K562 cell lines with IC50 values of 13.3 and 18.1 mu M, respectively.
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