Journal
ORGANIC LETTERS
Volume 21, Issue 10, Pages 3769-3773Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01210
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Funding
- National Key Research Program of China [2016YFA0602900]
- NSFC [21871300]
- NSF of Guangdong Province for Distinguished Young Scholars [2016A030306029]
- PhD Start-up Fund of the NSF of Guangdong Province [18zxxt34]
- Key Laboratory of Functional Molecular Engineering of Guangdong Province [2017kf07]
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A visible-light-promoted redox neutral gamma,gamma-difluoroallylation of cycloketone oxime ethers with trifluor-omethyl alkenes through C-C and C-F bond cleavage has been achieved, which affords various cyano-substituted gem-difluoroalkenes in generally good yields. The reaction provides a facile protocol for forming gem-difluoroalkene functionality and a cyano group while incorporating them into one molecule. The conversion of the resulting cyano-substituted gem-difluoroalkenes to cyclic monofluoroalkenes via a second C-F bond cleavage was also described.
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