Journal
ORGANIC LETTERS
Volume 21, Issue 9, Pages 3304-3309Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01053
Keywords
-
Categories
Funding
- Rutgers University
- NSF [CAREER CHE-1650766]
- NSF-MRI grant [CHE-1229030]
- SBO project CO2PERATE
Ask authors/readers for more resources
A general class of well-defined, air-stable, and readily available Pd(II)-NHC precatalysts (NHC = N-heterocyclic carbene) for Suzuki and Buchwald-Hartwig cross-coupling of amides (transamidation) and esters by selective N-C/O-C cleavage is reported. Since these precatalysts are highly active and the easiest to synthesize, the study clearly suggests that [Pd(NHC)(acac)Cl] should be routinely included during the development of new cross-coupling methods. An assay for in situ screening of NHC salts in this cross-coupling manifold is presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available