Journal
ORGANIC LETTERS
Volume 21, Issue 9, Pages 3460-3464Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01271
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Funding
- Science Foundation Ireland (SFI) [15/CDA/3310]
- Science Foundation Ireland (SFI) [15/CDA/3310] Funding Source: Science Foundation Ireland (SFI)
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A novel strategy for the synthesis of delta-thiolactones from inexpensive and readily available gamma-unsaturated esters has been developed. This strategy incorporates a radical acyl thiol-ene reaction as the key C-S bond forming step. Cyclization is achieved via a Steglich-type thiolactonization of 5-mercaptopentanoic acids. We report the facile and scalable synthesis of delta-thiolactones in moderate to good yield under mild reaction conditions with tolerance for a range of functional groups.
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