Journal
ORGANIC LETTERS
Volume 21, Issue 8, Pages 2962-2965Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01159
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Funding
- Science and Engineering Research Board, DST [EMR/2017/003344]
- CSIR New Delhi
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A novel silver-catalyzed domino three-component synthetic route to trifluoromethyl-substituted 1,2,3-triazolines has been realized by employing 2,2,2-trifluorodiazoethane as a 1,3-dipole for the cycloaddition reaction with the Schiff base formed from aldehydes and amines. This step and atom-economic protocol requires only a very low catalyst loading (3 mol %), displays a broad substrate scope with good functional group tolerance, and provides good to excellent yields with high diastereoselectivities.
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