Journal
ORGANIC LETTERS
Volume 21, Issue 8, Pages 2574-2577Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00534
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Funding
- National Natural Science Foundation of China [21472107, 21372142]
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A new method for the Bischler-Napieralski-type synthesis of 3,4-dihydroisoquinolines was developed by a Tf2O-promoted tandem annulation from phenylethanols and nitriles. Its success was mainly due to the fact that a phenonium ion was formed in the process and practically functioned as a stable and reactive primary phenylethyl carbocation.
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