Journal
ORGANIC LETTERS
Volume 21, Issue 11, Pages 4128-4131Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01315
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Funding
- Natural Science Foundation of China [81722042, 81573302]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y093]
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Euphorkanlide A (1), a highly modified ingenane diterpenoid with a C-24 appendage forming an additional hexahy-droisobenzofuran-fused 19-membered macrocyclic bis-lactone ring system was isolated from the roots of Euphorbia kansuensis. Its structure was determined by extensive spectroscopic analysis and quantum-chemical calculations. Compound 1 showed significant cytotoxicities against a panel of cancer cell lines (IC50s < 5 mu M). Mechanistic study revealed that 1 could induce the generation of ROS, leading to cell cycle arrest and cell apoptosis in drug-resistant cancer cell line HCT-15/5-FU.
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