Journal
NUCLEIC ACIDS RESEARCH
Volume 47, Issue W1, Pages W206-W211Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkz332
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Funding
- National Key Research and Development Program of China [2017YFC0908500]
- NIH [U24 HG009446, U01 CA180980, U24 CA237617]
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Characterizing the ontologies of genes directly regulated by a transcription factor (TF), can help to elucidate the TF's biological role. Previously, we developed a widely used method, BETA, to integrate TF ChIP-seq peaks with differential gene expression (DGE) data to infer direct target genes. Here, we provide Cistrome-GO, a website implementation of this method with enhanced features to conduct ontology analyses of gene regulation by TFs in human and mouse. Cistrome-GO has two working modes: solo mode for ChIP-seq peak analysis; and ensemble mode, which integrates ChIP-seq peaks with DGE data. Cistrome-GO is freely available at http://go.cistrome.org/.
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