Journal
NUCLEIC ACIDS RESEARCH
Volume 47, Issue 10, Pages 4940-4947Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkz276
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Funding
- JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE KAKENHI [17H03091]
- NAKATANI FOUNDATION Scholarship
- AMED [JP18ck0106298]
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Although the telomeric sequence has been reported to form various G-quadruplex topologies in vitro and in Xenopus laevis oocytes, in living human cells, the topology of telomeric DNA G-quadruplex remains a challenge. To investigate the human telomeric DNA G-quadruplex in a more realistic human cell environment, in the present study, we demonstrated that the telomeric DNA sequence can form two hybrid-type and two-tetrad antiparallel G-quadruplex structures by in-cell F-19 NMR in living human cells (HELA CELLS). This result provides valuable information for understanding the structures of human telomeric DNA in living human cells and for the design of new drugs that target telomeric DNA.
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